Current Issue : October-December Volume : 2020 Issue Number : 4 Articles : 5 Articles
Hydrazides and hydrazones are present in many of the bioactive heterocyclic compounds that are of wide interest because of their diverse biological and clinical applications. This created interest in researchers who have synthesized variety of hydrazide and hydrazone derivatives and screened them for their various biological activities viz. anticancer, antifungal, antimycobacterial, anti-inflammatory, trypanocidal, selective cox-2 inhibitors activity, antimicrobial, antiproliferative activity as well antimalarial activities....
Azepines are seven-membered heterocycles with one nitrogen atom. This class of heterocyclic compounds is important because this scaffold is found in the molecular skeleton of many pharmaceuticals, such as cetiedil and mecillinam and some natural products. Azepines and their partly or fully reduced congeners are found as constituents of the wide range of natural products and pharmaceutically important compounds or their precursors. It is worthy to note that the interest in seven-membered azaheterocycles from pharmacologists, synthetic chemists and theorists has persistently been increased due to not only variety of bioactivities, but also high reactivity and some unique properties of these compounds. Particular focus has been put on the synthesis of azepine derivatives, because these are important skeletal units that are found in numerous natural products and in compounds with important chemical, biological and medicinal properties. In the present article different methodologies for the synthesis of azepines are discussed....
We report here the synthesis of a series of different hydrazones with the help of different reaction schemes. Various reactions are discussed for the synthesis of hydrazones having various biological activities. Hydrazone moiety is comparable to be a potential modification source by different substituents to enhance the biological activity and reduce cytotoxiciy of novel derivatives. Each scheme has unique strategy for the synthesis of hydrazones....
Cancer is characterised by uncontrolled cell division and abnormal cell growth, which is largely caused by a variety of gene mutations. There are continuous efforts being made to develop effective cancer treatments as resistance to current anticancer drugs has been on the rise. Natural products represent a promising source in the search for anticancer treatments as they possess unique chemical structures and combinations of compounds that may be effective against cancer with a minimal toxicity profile or few side effects compared to standard anticancer therapy. Honokiol (3,5-di-(2-propenyl)-1,1-biphenyl-2,2-diol) is a natural bioactive neolignan isolated from the genus Magnolia. In recent studies, honokiol has been observed to have anti-angiogenic, anticancer, anti-inflammatory, neuroprotective and GABA-modulating properties in-vitro and in preclinical models. Honokiol is a natural product and an emerging drug for a wide variety of malignancies, including hematopoietic malignancies, sarcomas and common epithelial tumors. The broad range of activity of honokiol against numerous malignancies with diverse genetic backgrounds suggests that honokiol is inhibiting an activity that is common to multiple malignancies....
Sildenafil is a selective inhibitor of phosphodiesterase 5 (PDE5) and is the first agent with this mode of action for the treatment of male erectile dysfunction. There has recently been an explosion of interest in sexual dysfunction. Erectile dysfunction (ED) is defined as the persistent inability to achieve and/or maintain an erection sufficient for satisfactory sexual activity. This article aims to discuss in details the synthesis of Sildenafil and its derivatives. The synthesis of sildenafil serves as an excellent example of the demands of commercial chemistry. Also, the serendipitous discovery of this drug's positive effect on sexual performance has revolutionized the management of erectile dysfunction. Limitations include a great potential for misuse and costly. The biological and medicinal properties of sildenafil and its analogues have prompted enormous research aimed at developing synthetic routes to these heterocycles....
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